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Post-surgical applications may extend to 12 weeks with gradual tapering toward the end
In animal disease models, probucol protected the heart from doxorubicin-induced toxicity (Muldrew and Franks, 2009)
& Kawashima, S
Conversely, in chronic kidney disease, persistent endogenous stimuli (such as uric acid crystals and oxidative stress byproducts) induce continuous activation of the NLRP3 inflammasome
J Nutr Biochem 16 , 617624 (2005)
Thiopurine drugs have a relatively narrow therapeutic index and are capable of causing lifethreatening toxicity, most often myelosuppression (Sahasranaman et al., 2008)
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