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Factors such as regional BBB permeability, local metabolic demands, and microenvironmental conditions may influence the uptake and efficacy of PEGylated liposomes
The identified risk factors are limited to increasing age, family history of malignancy, certain genetic mutations (e.g., BRCA1 and BRCA2 ) and disease (Lynch syndrome)
Johnson DA, Amirahmadi S, Ward C et al (2009) The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
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