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Subjects were excluded if they had clinically significant concomitant diseases or disorders, clinically significant abnormal values in laboratory screening tests, any history of gastrointestinal surgery (except uncomplicated surgical procedures such as appendectomy and hernia surgery), or if they smoked more than five cigarettes or the equivalent per day

This stress damages melanocytes directly, causes mitochondrial dysfunction, and triggers what scientists call the unfolded protein response (UPR) an internal alarm system inside cells

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A slightly higher figure that bundles clinical time and responsive follow-up can represent better value than a bare medication price with little support attached

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