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If severe nausea persists with each dose, discontinuation is advisable

Prior to use, discuss dosing, administration, contraindications, and possible side effects with a knowledgeable clinician

Patients facing high OOP costs often discontinue therapy prematurely or dose less frequently to stretch prescriptions

These effects are observed in experimental settings, but there is no established safe dose for human use from clinical trials

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Peer review Peer review information Nature Medicine thanks Johnny Ludvigsson, Judy Zhong and the other, anonymous, reviewer(s) for their contribution to the peer review of this work