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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand name Ozempic) and chronic weight management (Wegovy)

The levels of glutathione in patients with serious diseases such as AIDS and cancer are very low

10.1016/j.ejphar.2019.01.030 59 SikiricP.HahmK

In brief, the first and rate-limiting step is the abstraction of a hydrogen atom by non-heme ferric iron (Fe(III)), involving a proton-coupled electron transfer in which the electron is transferred directly to the iron and the proton is acquired simultaneously by the hydroxide ligand in a concerted mechanism to give a substrate radical, while the iron atom is reduced to the ferrous state (Fe(II))

Two dockets: FDA-2025-N-6895 (peptide bulks list, closes July 22) and FDA-2026-N-2979 (meeting-specific docket)

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