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370 Accordingly, multiple strategies are being developed to circumvent or delay resistance, including rational drug combinations, novel therapeutic agents, microbiome interventions, adaptive treatment regimens, and advanced delivery systems (Fig
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Methods Culture conditions Three strains of anaerobic bacteria, isolated by culturomics studies 21,22,23 and obtained from the Collection de Souches de lUnit des Rickettsies (CSUR, Marseille, France), were used for this study: Clostridium sporogenes CSURP3957, Clostridium subterminale CSURP3759 and Romboutsia lituseburensis CSURP3909
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