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Our findings extend the therapeutic rationale for semaglutide in PCOS beyond metabolic benefits, suggesting potential direct ovarian protection via epigenetic modulation

Based on extrapolated benefits from weight reduction, this combination may be considered in patients with obesity and OA who are not candidates for incretin therapies

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NO production is known to decrease with aging primarily via decrements in the NOS-dependent pathway (Pourbagher-Shahri et al., 2021

Patients with severe heart failure or arrhythmias require monitoring because rapid shifts in free-fatty-acid metabolism can influence myocardial substrate utilization

3.2 Adaptive immune responses Adaptive immune mechanisms have also been implicated in PD