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These drugs mimic a natural gut hormone (GLP-1) that stimulates insulin secretion, slows digestion, and reduces appetite
Chewing gum Chewing gum increases saliva production, which can help neutralise acid and wash it back down into the stomach
Glucagon-like peptide 1 (GLP-1) receptor agonists, despite their clinical strength and surging demand, are hitting a wall of attrition fueled by systemic hurdles and behavioral friction
In the pre-specified in-study analysis based on pooled 9 mg and 12 mg retatrutide groups, 44 participants receiving retatrutide experienced a MACE-5 event, defined as all-cause death, myocardial infarction, stroke, heart failure event, or coronary revascularization, compared with 52 participants receiving placebo, corresponding to a hazard ratio of 0.82 (95% CI: 0.55-1.22)
Besides biological explanations, social factors like better adherence or a stronger motivation to lose weight among women might explain some of the differences
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