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10.1210/endo.137.6.8641190 Endocrinology 142 RobertsonM
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There was a 2-fold increase in the risk of major malformations and a 3-fold increase in the risk of major cardiac malformations when the fetus was exposed to more than 25 mg/day paroxetine
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This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits
Mechanistic analyses reveal glucagon receptor activation plays a crucial role through increased hepatic fatty acid oxidation and reduced de novo lipogenesis
