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The study cannot explain why lean body mass loss was greater with tirzepatide, which mimics the hormones GLP-1 and GIP, compared with semaglutide, which only mimics GLP-1

Starting dose of 0.25 mg = 7.5 units

Het-erogeneity of intraislet staining intensities in insulin and gluca-gon cells with islet-to-islet variability within the same donor may suggest differing rates of intracellular storage of GPX1 and its turnover within the same donor pancreas