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The Lancet , 392 (10144), 1519-1530
Managing Side Effects: The 2026 Protocol While highly effective, semaglutide dosing can lead to temporary gastrointestinal issues
Most patients reach the 2.4 mg maintenance dose around week 17
While rare, it's important to be aware that severe, persistent abdominal pain (especially if radiating to the back) with or without vomiting could indicate pancreatitis, a serious condition requiring immediate medical attention and discontinuation of Rybelsus
Consider patch testing before trying again
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