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With dramatic increases in GLP-1RA prescribing, potential shortages of semaglutide, in particular, and the recent availability of generic options for liraglutide, evidence-based guidance on preferential agents within this drug class became even more important. They chose to emulate a target trial as their study design because such a framework provides the closest approximation to randomized-controlled trial (RCT)-level evidence when head-to-head trials are unlikely to be conducted due to time, cost, and feasibility constraints

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