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While early immune responses may aid in the clearance of A and tau aggregates, prolonged activation of microglia and astrocytes leads to chronic inflammation and the release of pro-inflammatory cytokines such as IL-1 and TNF-, promoting neuronal damage in vulnerable brain regions like the neocortex and hippocampus [34,35,36]

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Based on mechanism, two interaction concerns are worth tracking: Additive collagen synthesis

Start with single peptides before stacking to understand individual responses