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Interestingly, when CU was combined with fluoxetine, the HAM-D17 score of the subjects reached 77.8%, although this result was not statistically different from the effects of CU or fluoxetine alone

Dysregulated mTORC1 and TFEB signaling exacerbate these autophagic defects, prompting research into the use of autophagy modulators as potential therapeutic strategies [144, 146]

Guieu R, Ruf J, Mottola G

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