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The FDA-approved titration schedule for Zepbound begins at 2.5 mg weekly, with increases no sooner than every 4 weeks through sequential doses of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and up to a maximum maintenance dose of 15 mg weekly, depending on individual response and tolerability

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A typical approach reduces Ozempic every 2-3 weeks in half-dose increments, allowing each step to stabilize before the next reduction