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While GLP-1 agonists produce dramatic results for many patients, a meaningful subset achieves suboptimal weight loss or experiences diminishing efficacy over time

A t-test for independent samples was used for comparisons of means between two groups for normally distributed variables

Any retatrutide obtained outside of a formal, ethics-approved clinical trial is classified as a research chemical and is not intended for human use under current UK regulations

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Phase 2 results for a weekly injection found a mean 24.3% weight loss at 36 weeks with the 60mg dose