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Although metformin has its benefits, it is not enough for many patients, particularly those with A1c levels that refuse to come down

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A., Baumann, G., Roth, J., Harman, S

[12] Beyond that specific episode, GH secretagogues generally can affect glucose metabolism and insulin sensitivity: raising GH tends to oppose insulin action, and studies of oral ghrelin-mimetic secretagogues in older adults have documented measurable effects on glucose handling alongside their GH and IGF-I elevation