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doi:10.1111/pce.12563

NICE obesity guidance (CG189) directs individuals towards structured lifestyle interventions, behavioural support, and, where appropriate, pharmacological or surgical options No authorised health claims for L-carnitine and weight loss or fat metabolism exist on the GB Nutrition and Health Claims Register In summary, while L-carnitine pills are not harmful for most healthy adults when taken at recommended doses, the evidence supporting their use specifically for weight loss remains insufficiently robust to justify clinical endorsement

And they can be quite uncomfortable

These side effects usually dont last long

Suita S, Masumoto K, Yamanouchi T, Nagano M, Nakamura M

PARPs, involved in DNA repair, consume NAD+ during frequent repair events in older cells