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penneri alone was unable to consume BB or produce TMA, whereas only E

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GI-sensitive individuals benefit from extended 16-20 week titrations and may find optimal results at maintenance doses of 1.8-2.0mg weekly rather than pushing to 2.4mg

Furthermore, there was a dose-dependent increase in the number of therapeutic goals attained with tirzepatide, suggesting that for individuals not achieving therapeutic targets, higher doses of tirzepatide may represent a clinically relevant approach to improve disease management