j) History of consumption of one or more of the below, 48 hours prior to dosing: Xanthine containing food or drinks such as cola, chocolate, coffee or tea, citrus fruits or items (lime, lemon, and orange), alcohol and any other food or beverage known to have interactions as deemed by the investigator [10,11]
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These changes increase tyrosinase activity, promote eumelanin biosynthesis in melanosomes, and enhance melanosome maturation and transfer to keratinocytes, yielding photoprotective pigmentation