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The conversion of NADH to NAD+ is regulated to markedly reduce the NAD+/NADH ratio, ultimately abrogating ROS production, which is responsible for aging

"If we can kind of, like, tease out what is the effect of weight loss versus what is the direct effect of these medications on the upper airway, that will be very interesting." The most common side effects of GLP-1 drugs, including tirzepatide, are nausea, vomiting, diarrhea and constipation

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DSIP directly modulates this axis

But thats a huge challenge until this is approved by the FDA for addiction related purposes, then the drug itself is gonna be, you know, difficult to access for millions of Americans