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doi: 10.1056/NEJMoa1607141 19 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

Brown found that the separation of breast cancer cells from the extracellular matrix (ECM) significantly decreased cell viability, whereas cell viability was improved by the ferroptosis inhibitor Fer-1, demonstrating that separation of cells from the ECM is a pro-ferroptosis response

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This process converts amino acids from muscle tissue into glucose