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Key Takeaways Protein for GLP-1 weight loss is a lean-mass, appetite, and meal-structure strategy

In this rigorous double-blind trial, 529 patients with HFpEF and obesity were randomized to once-weekly semaglutide 2.4 mg or placebo for 52 weeks

Depression and mood changes, though not commonly reported with GLP-1 receptor agonists, should be considered in the differential diagnosis of fatigue

The medication works through several complementary mechanisms

There are other mechanisms by which circulating incretin mimetics can influence deep brain function without crossing the blood-brain barrier

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