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Koitabashi N, Kass DA (2012) Reverse remodeling in heart failuremechanisms and therapeutic opportunities

Natural GLP-1 is a peptide hormone that helps regulate blood sugar, digestion, and appetite

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Unlike older insulin secretagogues that dump insulin regardless of glucose state, semaglutide's mechanism is glucose-dependentmeaning it releases insulin in response to meals and elevated blood sugar, not during fasting or low-glucose periods

Results from clinical trials dont always reflect what happens in daily life