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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis

[5] It is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ROS)

Serious but rare adverse effects require clinical vigilance

Drug Interactions and Limitations of Use Semaglutide slows gastric emptying and may affect the absorption of oral medications

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