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Amylin, a neuroendocrine anorexigenic polypeptide hormone, with its multi-faceted effects in glucose regulation, weight management and potential CV and neuroprotective functions, represents an attractive new therapeutic target, albeit not without challenges and limitations [29]

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Adjusting the dosage schedule, recommending dietary changes, or temporarily pausing treatment are all strategies providers may use to improve tolerability

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At 52 weeks, tirzepatide-treated participants spent significantly more time in the target range compared to the insulin group