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Thirdly, we expected to find that some of the insufficiencies would be associated with at least one of the diagnostic categories
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
Glutathione and its anti-aging and antimelanocitic effects 24
doi:10.1074/jbc.270.22.13399
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