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Oral glutathione is a viable alternative, particularly in liposomal form or at higher doses sustained over months, where a 6-month RCT documented 30-35% increases in blood and lymphocyte glutathione

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Moreover, the presence of the glycolytic enzymes HK2 and PKM protein in the mitochondrial lysate after removing the outer mitochondrial membrane with protein kinase K indicated that HK2 and PKM are localized to the intermembrane space of mitochondria (Fig