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When to Expect Improvement and When to Contact Your Provider Sulfur burps are nearly always a temporary side effect that improves significantly within 48 weeks as your digestive system acclimates to semaglutide's slower stomach emptying

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4 The accompanying GOV.UK patient page, last updated in February 2026, sets out the washout periods clearly: tirzepatide needs at least one month, semaglutide-based medications need at least two months, and liraglutide can be stopped just before trying because it leaves the body much more quickly

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Patients should work closely with their healthcare providers to adjust their Semaglutide dosage or timing if necessary, based on their blood glucose monitoring

For another 26 weeks, participants received no additional medication or surgery