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Researchers observed that PE-22-28 interacts with TREK-1 through binding to the sortilin/NTSR3 receptor-associated complex, blocking potassium conductance and increasing neuronal excitability in serotonergic and other mood-relevant neuronal populations
To test this hypothesis, we designed peptides by substituting negatively charged amino acids and those with a CSP greater than two standard deviations 38 with alanine
This was predicted to stabilise the N-terminal -helix (5-18) of the peptide through formation of an intramolecular salt bridge, as observed in a crystal structure of CagriBB fused at the C-terminal end of maltose-binding protein (PDB:7BG0) 2
Brain capillaries and cholinergic neurons persist in organotypic brain slices in the absence of blood flow
The data are presented as the percentage of control
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