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Platelet-derived mediators can recruit and activate endothelial and immune cells, producing an initial inflammatory spike that elevates NF-B and its downstream apoptotic signals 39

Circulating plasma GLP-1 levels rise from approximately 510 pmol/L in the fasted state to 1550 pmol/L in the postprandial state, with peak levels depending on meal composition, caloric density, and rate of gastric emptying

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