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This is where the concept of bioavailability becomes essential
Current studies have revealed a strong link between ferroptosis and the GSH system, which has become a hotspot in the field of CVDs
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Accumulation of cytosolic succinate results the inhibition of the 2-oxoglutarate and Fe 2+ -dependent dioxygenases [prolyl hydroxylase domain (PDH) enzymes] responsible for the hydroxylation of the -subunit (HIF-1) of HIF-1
Kidney Int (2019) 96(6):13818
Macrophages in the pathogenesis of atherosclerosis
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