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A 2025 systematic review examined the peptide from a musculoskeletal research perspective, screening 544 articles published between 1993 and 2024 and including 36 studies, of which 35 were preclinical [9]
The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]
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Its mechanism of action revolves around modulating key pathways involved in inflammation, angiogenesis (the formation of new blood vessels), and collagen production
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