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CJC-1295, animal model Alba et al., 2006 (Endocrinology): once-daily CJC-1295 normalized growth in a GHRH-knockout mouse, supporting the GHRH-receptor mechanism

Serine synthesis by the rat kidney

Methionine: 0.1 to 1 mM in cell culture, 100 to 500 mg per kg in animal models

The three compounds can be sourced and reconstituted separately, which allows independent dosing but adds cold-chain items and sterile draws

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The management of patients with mild GO represents a challenge for endocrinologists and ophthalmologists