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Studies exploring this therapy report a cost of US$545 per kilogram weight loss attained, with a cost of US$122,640 per QALY gained [13]
Studies have shown that caffeic acid can inhibit the expression of Keap1, reduce the stabilization of the Keap1 and Nrf2 complex, thereby activate Nrf2 and upregulate the expression of downstream antioxidant enzymes NQO1 and HO-1 (Pang et al., 2016)
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When covered, out-of-pocket cost can be much lower than list price, though coverage for weight loss is often restricted and may require prior authorization
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