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The NICE Guideline NG239 (2024) and the AAFP clinical review both support this approach

In diet-induced obese models, it produced a 7-10% reduction in body weight in just 11 days by increasing the basal metabolic rate

The OPTIONS study was described as a double-blind, placebo-controlled trial in 502 adults with obesity who received oral AOD9604 or placebo once daily for 24 weeks together with a diet-and-exercise program

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This might seem counterintuitive if you've heard otherwise, but it highlights the complexity of nutritional science

NAD+ or tightened recovery support is what addresses it