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Serum Potassium In the 1-year controlled trials of phentermine and topiramate extended-release in adults, the incidence of persistent low serum potassium values (less than 3.5 mEq/L at two consecutive visits or at the final visit) during the trial was 3.6% for phentermine and topiramate extended-release 7.5 mg/46 mg dose and 4.9% for phentermine and topiramate extended-release 15 mg/92 mg, compared to 1.1% for placebo
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Patients should maintain adequate hydration, especially during the initial weeks when nausea may reduce fluid intake, and continue balanced nutrition despite reduced appetite to ensure adequate protein and micronutrient intake
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