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Large-scale profiling leads us to the most biologically relevant signals, whether they are already known compounds or have yet to be characterized
However, compounded semaglutide medicines are not FDA-approved
Further, the lack of correlation with markers of kidney function questions the use of ADC as a biomarker of a positive treatment response
Each compound adds dose changes, timing, storage, measurement needs, and possible adverse effects
Clinical trials have found that most side effects improve with time
Patient safety advice includes staying well-hydrated, reporting persistent gastrointestinal symptoms, and seeking urgent medical attention for severe abdominal pain, signs of dehydration, or symptoms of lactic acidosis (muscle pain, breathing difficulties, unusual tiredness)
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