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Endocrine , 46, 445454

Along these lines, Zhang et al [39] described a novel mechanism in the mouse whereby microRNA miR-27a-5p containing extracellular vesicles released from visceral adipocytes was taken up by beta cells resulting in beta cell dysfunction due to the downregulation of adenylate cyclase 1 (encoded by Adcy1 ) and L-type Ca 2+ channel subunit 1c (encoded by Cacna1c [ Cav1.2 ])