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Gut microbiota-brain interaction: an emerging immunotherapy for traumatic brain injury
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DAMPs bind to TLRs, activating the NF-B pathway, promoting its nuclear translocation, and inducing the transcriptional expression of various pro-inflammatory cytokines (such as TNF-, IL-1, IL-6) and chemokines (such as monocyte chemotactic protein-1, MCP-1) [25]
Amato M, Polizzi A, Blasi A, Grippaudo C, Isola G
This definitional vagueness poses significant challenges to the development of objective and reproducible criteria for evaluating efficacy
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