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KRAS can activate downstream factors through phosphorylation reactions, and ultimately promote cell proliferation by regulating signaling pathways such as the RAS-RAF-MEK-ERK and PI3K-AKT pathways 42

Underlying mechanisms have been defined and show that the lactate-induced inhibition of CD4 + T cell movement results from an interference with glycolysis that is activated when the chemokine CXCL10 engages the chemokine receptor CXCR3

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