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PMID: 20101189 Stanley TL, et al
Eight-week-old female Balb/c mice (Oriental Yeast) were utilized for in vivo transfection and knock-in experiments
Recently, it has been demonstrated that mice with a deletion of the GLP-1 receptor only in -cells, are resistant to the beneficial anti-diabetic effect of a vertical sleeve-gastrectomy ( It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology
These recommendations closely align with those of the American Society of Anesthesiologists (June 28-2023)
The first trial tested an earlier GLP-1 medication known as exenatide
