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Cosmetic changes, including hair loss, muscle loss, loose or sagging skin, and more pronounced wrinkles

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At the same time, the literature has gaps: many trials are powered for glycemic or weight outcomes, not for fertility, longterm sex steroid levels, or adrenal function

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Semaglutide (available under brand names of Wegovy and Ozempic) is an anti-diabetic medication and is also used for long-term weight management