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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition
W.et al (2018)
The antioxidant activity of saffron is mainly due to crocin, and the synergistic effect of crocin and crocetin enhances oxygen diffusion and enhances ocular blood flow in the retina and choroid, which are crucial in the disease [230]
One of its most prominent functions is the transformation of harmful substances in the body
Key finding: Upregulated SOD, glutathione S-transferase, and endogenous antioxidant genes while suppressing pro-oxidant expression reversing age-related oxidative decline
