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Materials and methods Animals and ethics statement Experiments were carried out according to EU directives and French regulations (Directive 2010/63 / EU, 2010

10.1016/S0079-6603(02)72070-9 199 WheelerG

Integrated Drug Discovery Integrated Drug Discovery Overview We deliver truly integrated drug discovery programs

Targeting both is less like doubling a dose and more like sending the same instruction down two independent phone lines

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Pre-Blend Reconstitution Math (12.5/2.5 mg, 15 mg total) Metric Blend composition Value 12.5 mg retatrutide + 2.5 mg cagrilintide Metric BAC water added Value 2.5 mL Metric Concentration Value 5.0 mg/mL retatrutide + 1.0 mg/mL cagrilintide Metric Ratio held constant Value 5:1 (reta : cag) What Each Draw Delivers (12.5/2.5 mg Pre-Blend) Draw Volume 0.20 mL Units 20 units Retatrutide 1.0 mg Cagrilintide 0.2 mg Draw Volume 0.40 mL Units 40 units Retatrutide 2.0 mg Cagrilintide 0.4 mg Draw Volume 0.60 mL Units 60 units Retatrutide 3.0 mg Cagrilintide 0.6 mg Draw Volume 0.80 mL Units 80 units Retatrutide 4.0 mg Cagrilintide 0.8 mg Draw Volume 1.20 mL Units 120 units* Retatrutide 6.0 mg Cagrilintide 1.2 mg Draw Volume 1.60 mL Units 160 units* Retatrutide 8.0 mg Cagrilintide 1.6 mg Draw Volume 2.40 mL Units 240 units* Retatrutide 12.0 mg Cagrilintide 2.4 mg * Volumes above 100 units exceed a standard 1 mL insulin syringe - split into two injections or use a larger syringe