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In a multiple-ascending dose study in NAFLD subjects, about 20% of whom had biopsy-confirmed NASH, weekly or every-other-weekly administration of BIO89-100 for 12 weeks reduced serum triglycerides by 1828%, reduced liver fat by 3660%, and increased adiponectin by 2361% relative to baseline (299)

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Then we evolved even further, to looking at a global genome assessment and trying to specifically treat the genes in whatever area the global genome assessment flagged