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Consistently, we found that the either T3 or MB07811 effect on the Cyp8b1 mRNA expression could be attenuated in the liver of LTRKO mice (Fig
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Importantly, our cell culture observations were corroborated by our results obtained in animal studies, suggesting that increased hepatic protein S -glutathionylation contributes to NAFLD pathogenesis via suppression of the NF-B signaling pathway in hepatocytes
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