Further research is needed to compare tesofensine with other drugs and evaluate its tolerability in larger clinical trials.The authors of the study highlight that tesofensine at a low dose of 0.25 mg leads to greater weight loss compared to orlistat and similar weight loss as sibutramine and rimonabant
Remember that medications are just one part of a comprehensive approach to managing diabetes and weight, and lifestyle changes are equally important
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Also, LBM reduction was often assessed using BIA or DXA, both of which have limitations in distinguishing between muscle, organ mass, and extracellular fluid