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For patients considering retatrutide when it becomes available in 2028, dysesthesia should factor into the risk-benefit calculation alongside GI side effects and cost
10.1016/S1569-1993(03)00097-3 103 GrieseM.KapplerM.EismannC.BallmannM.JungeS.RietschelE.et al (2013)
Some describe being told their refund is "processing" only to never receive it
doi:10.1210/jc.2018-00070 Rodbard HW, Lingvay I, Reed J, et al
The severity and duration depend heavily on the dose you were taking and how long you had been on the medication
arthralgia incidence in trials is generally similar to placebo Rapid weight loss from GLP-1 treatment may alter biomechanical loading on joints, causing temporary adjustment-related discomfort Patients prescribed GLP-1 medications often have type 2 diabetes or obesity, conditions independently associated with increased osteoarthritis rates Seek medical advice for severe, worsening, or persistent joint pain, or if accompanied by swelling, redness, warmth, or systemic symptoms Report suspected medication side effects through the MHRA Yellow Card scheme to support ongoing safety monitoring Table of Contents Understanding GLP-1 Medications and Their Common Side Effects GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda), most commonly cause gastrointestinal side effects such as nausea, vomiting, and diarrhoea
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