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Epidemiology Lupus affects up to 1.4 million people in the United States

UV-damaged tissue models showed particular responsiveness to GHK-Cu administration, with elastosis markers improving by 25% and pigmentation irregularities decreasing by 40% in intensity in experimental systems

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This can lead to the hypothesis that such compounds, since they reverse the disease-related gene expression pattern, are potential therapeutics for that disease

This shift results in reduced ATP efficiency, lactate accumulation, excessive reactive oxygen species production, and amplification of inflammatory responses, thereby establishing a self-sustaining immunometabolic vicious cycle

Park NC, Kim TN, Park HJ